Papers

Jason Plemel Pubmed: Pubmed

Jason Plemel ResearchGate: ResearchGate

Recent Publications

Hammond BP, Hahn E, Lee KV, Kerr BJ, Plemel JR. (2026) Inflammatory mediators both directly and indirectly promote microglial proliferation. Glia 74(5):e70150.

Zia S, Traetta ME, Baaklini CS, Hammond BP, John RK, Souter KM, Meijns N, Afun LKA, Panda S, González Ibáñez F, Burr MK, Dhupia E, Rathod AM, Faria AO, Zaveri D, Challa S, Hahn E, Manesh SB, Lee KV, Ho MFS, Friedman TN, Maguire AD, Pang A, Farkas O, Szulc B, Tenorio L, Vyas D, La Caprara OR, Tetzlaff W, Sinha S, Duncan GJ, Voronova A, Kerr BJ, Tremblay ME, Biernaskie J, Schenk G, Plemel JR. (2025) Age-impaired remyelination is associated with dysregulated microglial transitions. Nature Communications 16:9951.

John RK, Vogel SP, Zia S, Lee KV, Nguyen AT, Torres-Espin A, Fenrich KK, Ng C, Schmidt EKA, Vavrek R, Raposo PJF, Smith K, Fouad K*, Plemel JR*. (2025) Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states. Journal of Neuroinflammation 22(1):56. *equal contributions

Eskandari-Sedighi G, Crichton M, Zia S, Gomez-Cardona E, Cortez LM, Patel ZH, Takahashi-Yamashiro K, St Laurent CD, Sidhu G, Sarkar S, Aghanya V, Sim VL, Tan Q, Julien O, Plemel JR, Macauley MS. (2024) Alzheimer’s disease-associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice. Molecular Neurodegeneration 19:42.

Baaklini CS, Ho MFS, Lange T, Hammond BP, Panda SP, Zirngibl M, Zia S, Himmelsbach K, Rana H, Phillips B, Antoszko D, Ibanga J, Lopez M, Keough MB, Caprariello AV, Kerr BJ, Plemel JR. (2023) Microglia promote remyelination independent of their role in clearing myelin debris. Cell Reports 42(12):113574.

Zia S, Hammond BP, Zirngibl M, Sizov A, Baaklini CS, Panda SP, Lee KV, Mainali A, Burr MK, Williams S, Caprariello AV, Simmen T, Kerr BJ, Plemel JR. (2022) Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance. Molecular Neurodegeneration 17(1):82.

Bhattacherjee A, Jung JS, Zia S, Ho MH, Eskandari-Sedighi G, St Laurent CD, McCord KA, Bains A, Sidhu G, Sarkar SS, Plemel JR, Macauley MS. (2021) The CD33 short isoform is a gain-of-function variant that enhances Aβ1-42 phagocytosis in microglia. Molecular Neurodegeneration 16(1):19.

Plemel JR, Stratton JA, Michaels NJ, Rawji KS, Zhang E, Sinha S, Baaklini CS, Dong Y, Ho M, Thorburn K, Friedman TN, Jawad S, Silva C, Caprariello AV, Hoghooghi V, Yue J, Kerr BJ, Midha R, Stys PK, Biernaskie J, Yong VW. (2020) Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. Science Advances 6(3):eaay6324.

Baaklini CS, Rawji KS, Duncan GJ, Ho M, Plemel JR (2019) Central nervous system remyelination: roles of glia and innate immune cells. Frontiers in Molecular Neuroscience Sept 19;12:225 (Journal Impact Factor 5.076; PMID 31616249)

Faissner S, Plemel JR, Gold R, Yong VW (2019) Progressive multiple sclerosis: therapeutic strategies to address the unmet clinical need. Nature Reviews Drug Discovery Aug 9 (Journal Impact Factor 47.1; PMID 31399729)

Plemel JR, Michaels N, Weishaupt, Caprariello AV, Keough MB, Rogers JA, Yukseloglu A, Lim J, Patel V, Rawji KS, Jensen SK, Teo W, Heyne B, Whitehead S, Stys PK, Yong VW. (2017) Mechanisms of lysophosphatidylcholine-induced demyelination: a primary lipid disrupting myelinopathy worsened by inadequate buffering. Glia 66(2): 327-347 (Journal Impact factor 5.997; PMID 29068088)

Micu I*, Plemel JR*, Caprariello AV*, Nave KA, Stys PK. Axo-myelinic neurotransmission: a novel mode of cell signaling in the central nervous system. (2017) Nature Reviews Neuroscience 19(1): 49-58 (Journal Impact factor 32.653; PMID: 29238086)    * These authors contributed equally

 Plemel JR, Liu WQ, Yong VW. (2017) Remyelination therapies: a new direction and challenge in multiple sclerosis. Nature Reviews Drug Discovery. 16(9): 617-634 (Journal Impact Factor 47.1; PMID 28685761)

 Plemel JR, Caprariello AV, Keough MB, Henry TJ, Tsutsui S, Chu TH, Schenk GJ, Klaver R, Yong VW, Stys PK. (2017) Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis. Journal of Cell Biology 216 (4): 1163-1181 (Journal Impact Factor 9.834; PMID: 28631093)

Plemel JR, Keough MB, Duncan GJ, Sparling JS, Yong VW, Stys PK, Tetzlaff W. (2014) Remyelination after spinal cord injury: is it a target for repair? Progress in Neurobiology 117: 54-72 (Journal Impact factor 13.177; PMID: 24582777)

Plemel JR, Manesh SB, Sparling JS, Tetzlaff W. (2013) Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression. Glia 61(9):1471-1487 (Journal Impact factor 5.997; PMID:23839973)

Plemel JR, Chojnacki A, Sparling JS, Liu J, Plunet W, Park S, Weiss S, Tetzlaff W. (2011) Platelet-derived growth factor-responsive neural precursors (PRPs) give rise to myelinating oligodendrocytes after transplantation into the spinal cords of contused rats and dysmyelinated mice. Glia 59(12): 1891-1910 (Journal Impact factor 5.997; PMID:22407783)